High-level talks to forge a ­12-nation trade deal spanning the Pacific broke up Friday without resolving contentious disputes over Canadian dairy tariffs, the protection of cutting-edge drugs known as “biologics” and Japanese access to the North American automobile market.

Negotiators said they would continue to seek agreement over the coming months, but the failure to wrap up the accord, known as the Trans-Pacific Partnership, was a setback for President Obama, who hopes that the completion of a deal will be one of his signature achievements.

The secret negotiations have drawn sharp criticism from unions, human rights groups and the overwhelming majority of congressional Democrats.

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